Best local LLMs for the AMD Instinct MI350X

Each list assumes the context that task needs, so a model that fits for chat may rank lower for long documents.

General chat at 8K context

  1. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (284B-A13B) Q6_K · 172 tok/s · Runs well (tight fit)
  2. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q6_K · 150 tok/s · Runs well (tight fit)
  3. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Hunyuan Hy3 (295B-A21B) Q6_K · 139 tok/s · Runs well (tight fit)
  4. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. K2-Horizon (375B-A23B) Q5_K_M · 147 tok/s · Runs well (tight fit)
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.5 (310B-A15B) Q6_K · 162 tok/s · Runs well (tight fit)

Coding at 32K context

  1. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (284B-A13B) Q6_K · 172 tok/s · Runs well (tight fit)
  2. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (April 2026) Q5_K_M · 187 tok/s · Runs great
  3. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q6_K · 150 tok/s · Runs well (tight fit)
  4. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Hunyuan Hy3 (295B-A21B) Q6_K · 139 tok/s · Runs well (tight fit)
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.5 (310B-A15B) Q6_K · 162 tok/s · Runs well (tight fit)

Reasoning at 32K context

  1. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (284B-A13B) Q6_K · 172 tok/s · Runs well (tight fit)
  2. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (April 2026) Q5_K_M · 187 tok/s · Runs great
  3. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q6_K · 150 tok/s · Runs well (tight fit)
  4. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Hunyuan Hy3 (295B-A21B) Q6_K · 139 tok/s · Runs well (tight fit)
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.5 (310B-A15B) Q6_K · 162 tok/s · Runs well (tight fit)

Documents (RAG) at 32K context

  1. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (April 2026) Q5_K_M · 187 tok/s · Runs great
  2. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q6_K · 150 tok/s · Runs well (tight fit)
  3. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Hunyuan Hy3 (295B-A21B) Q6_K · 139 tok/s · Runs well (tight fit)
  4. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.6 Flash (310B-A15B) Q6_K · 162 tok/s · Runs well (tight fit)
  5. 90Excellent quality (A+) · 90 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiniMax M2.1 (230B-A10B) Q6_K · 188 tok/s · Runs great

Agents & tools at 64K context

  1. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (284B-A13B) Q6_K · 172 tok/s · Runs well (tight fit)
  2. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. DeepSeek V4 Flash (April 2026) Q5_K_M · 187 tok/s · Runs great
  3. 95Excellent quality (A+) · 95 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q6_K · 150 tok/s · Runs well (tight fit)
  4. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Hunyuan Hy3 (295B-A21B) Q6_K · 139 tok/s · Runs well (tight fit)
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.5 (310B-A15B) Q6_K · 162 tok/s · Runs well (tight fit)

Reverse engineering at 32K context

  1. 96Excellent quality (A+) · 96 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 98/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q8_0 · 192 tok/s · Runs great
  2. 94Excellent quality (A+) · 94 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. Nex N2.6 (321B-A18B) Q5_K_M · 165 tok/s · Runs great
  3. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. GLM-5.3 Flash (320B-A18B) Q5_K_M · 165 tok/s · Runs great
  4. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. MiMo V2.6 Flash (310B-A15B) Q5_K_M · 177 tok/s · Runs great
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. Step 3.7 Flash (198B-A11B) Q8_0 · 157 tok/s · Runs great

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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