GLM-4.6 (355B-A32B) on AMD Instinct MI300X

Can the AMD Instinct MI300X run GLM-4.6 (355B-A32B)?

Yes, it runs well (tight fit)

Runs well (tight fit). At Q3_K_M it needs about 188 GB of 192 GB usable, with an estimated speed of 131 tok/s.

Best quant: Q3_K_M
Generation speed: 131 tok/s
Prompt processing: 3,166 tok/s
First token (1K prompt): 0.3 s
Largest safe context: 18K

Best app to run it on the AMD Instinct MI300X

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull unsloth/GLM-4.6-GGUF:Q3_K_M

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull unsloth/GLM-4.6-GGUF:Q3_K_M

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

Want an agent? GLM-4.6 (355B-A32B) supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download GLM-4.6 (355B-A32B)

Recommended for the AMD Instinct MI300X: Q3_K_M. Every other quantization has its own download link in the table below.

Ollama

Ollama only offered this as a cloud model, and has since retired it. To run it locally, use the GGUF files below with llama.cpp or LM Studio.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q3_K_M files (opens in a new tab)

huggingface.co/unsloth/GLM-4.6-GGUF (opens in a new tab)

ollama run hf.co/unsloth/GLM-4.6-GGUF

Original weights · Hugging Face

Full-precision files from Zhipu AI, for fine-tuning, vLLM, Transformers.

huggingface.co/zai-org/GLM-4.6 (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Zhipu AI. The weights themselves download from Hugging Face.

github.com/zai-org/GLM-4.5 (opens in a new tab)

git clone https://github.com/zai-org/GLM-4.5

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 70Great quality (A) · 70 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 85/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q3_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welltight fit: How well it runs on the AMD Instinct MI300X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	31.8 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	85.8 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI300X

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	156 GB	192 GB	151 tok/s	Runs great	58Good quality (B) · 58 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q3_K_M`	188 GB	192 GB	131 tok/s	Runs welltight fit	70Great quality (A) · 70 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 85/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q4_K_M`	231 GB	192 GB	—	Won't run	79Great quality (A) · 79 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q5_K_M`	267 GB	192 GB	—	Won't run	81Great quality (A) · 81 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q6_K`	306 GB	192 GB	—	Won't run	83Great quality (A) · 83 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q8_0`	391 GB	192 GB	—	Won't run	84Great quality (A) · 84 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`F16`	727 GB	192 GB	—	Won't run	84Great quality (A) · 84 of 100: how capable the model is at F16, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

79Great quality (A) · 79 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 87/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (512 GB) Q4_K_M · 24.8 tok/s · Runs well
58Good quality (B) · 58 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (256 GB) Q2_K · 39.0 tok/s · Runs great
58Good quality (B) · 58 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 64/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) Q2_K · 32.5 tok/s · Runs well (over GPU memory limit)
79Great quality (A) · 79 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI350X Q4_K_M · 140 tok/s · Runs great
79Great quality (A) · 79 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking. Apple M5 Ultra (512 GB) Q4_K_M · 35.0 tok/s · Runs great
79Great quality (A) · 79 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI325X Q4_K_M · 119 tok/s · Runs well (tight fit)

Quick answers

How much memory does GLM-4.6 (355B-A32B) need on the AMD Instinct MI300X 192GB?

At Q3_K_M it needs about 188 GB. The AMD Instinct MI300X 192GB has 192 GB usable.

How fast is GLM-4.6 (355B-A32B) on the AMD Instinct MI300X 192GB?

About 131 tok/s at Q3_K_M, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of GLM-4.6 (355B-A32B) should I use on the AMD Instinct MI300X 192GB?

Q3_K_M. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.