Laguna S 2.1 (118B-A8B) on AMD Instinct MI300X

Can the AMD Instinct MI300X run Laguna S 2.1 (118B-A8B)?

Yes, it runs great

Runs great. At Q8_0 it needs about 136 GB of 192 GB usable, with an estimated speed of 151 tok/s.

Best quant: Q8_0
Generation speed: 151 tok/s
Prompt processing: 12,664 tok/s
First token (1K prompt): 0.3 s
Largest safe context: 284K

Best app to run it on the AMD Instinct MI300X

On Linux

vLLM

Inference server · runs on vLLM

The full model fits in GPU memory at 8-bit, so it can batch many requests: best for serving a team or an app.

vllm serve poolside/Laguna-S-2.1

Lemonade AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.
LM Studio Point-and-click: search, download and chat in one window.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull poolside/Laguna-S-2.1-GGUF:Q8_0

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

Want an agent? Laguna S 2.1 (118B-A8B) supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Laguna S 2.1 (118B-A8B)

Recommended for the AMD Instinct MI300X: Q8_0. Every other quantization has its own download link in the table below.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q8_0 file (opens in a new tab)

huggingface.co/poolside/Laguna-S-2.1-GGUF (opens in a new tab)

ollama run hf.co/poolside/Laguna-S-2.1-GGUF:Q8_0

Original weights · Hugging Face

Full-precision files from Poolside, for fine-tuning, vLLM, Transformers.

huggingface.co/poolside/Laguna-S-2.1 (opens in a new tab)

No sign-in needed.

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q8_0, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great: How well it runs on the AMD Instinct MI300X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	38.7 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	93.7 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI300X

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	58.8 GB	192 GB	250 tok/s	Runs great	60Good quality (B) · 60 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking.	GGUF files (opens in a new tab)
`Q3_K_M`	69.4 GB	192 GB	230 tok/s	Runs great	72Great quality (A) · 72 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	GGUF files (opens in a new tab)
`Q4_K_M`	83.5 GB	192 GB	209 tok/s	Runs great	81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 86/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q5_K_M`	95.3 GB	192 GB	191 tok/s	Runs great	83Great quality (A) · 83 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 88/100 (quality, fit, speed and memory use) sets the ranking.	GGUF files (opens in a new tab)
`Q6_K`	108 GB	192 GB	176 tok/s	Runs great	85Excellent quality (A+) · 85 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking.	GGUF files (opens in a new tab)
`Q8_0`	136 GB	192 GB	151 tok/s	Runs great	86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`F16`	247 GB	192 GB	—	Won't run	86Excellent quality (A+) · 86 of 100: how capable the model is at F16, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (256 GB) Q8_0 · 45.5 tok/s · Runs great
85Excellent quality (A+) · 85 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) Q6_K · 58.0 tok/s · Runs great
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell Q4_K_M · 143 tok/s · Runs great
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX Spark N1X (6144-core GPU) (128 GB) Q4_K_M · 39.9 tok/s · Runs great
83Great quality (A) · 83 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Max (128 GB) Q5_K_M · 49.3 tok/s · Runs well (tight fit)
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GB10 (128 GB) Q4_K_M · 36.7 tok/s · Runs great

Quick answers

How much memory does Laguna S 2.1 (118B-A8B) need on the AMD Instinct MI300X 192GB?

At Q8_0 it needs about 136 GB. The AMD Instinct MI300X 192GB has 192 GB usable.

How fast is Laguna S 2.1 (118B-A8B) on the AMD Instinct MI300X 192GB?

About 151 tok/s at Q8_0, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Laguna S 2.1 (118B-A8B) should I use on the AMD Instinct MI300X 192GB?

Q8_0. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.