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Can the AMD Ryzen AI Max+ 395 (128 GB) run Llama 3.1 405B Instruct?

50Fair quality (C) · 50 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 6/100 (quality, fit, speed and memory use) sets the ranking.

No, it doesn’t fit

No. Llama 3.1 405B Instruct needs about 175 GB even at Q2_K; the AMD Ryzen AI Max+ 395 (128 GB) has 96.0 GB usable.

Download Llama 3.1 405B Instruct

Recommended: Q2_K. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run llama3.1:405b-instruct-q2_K

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q2_K file (opens in a new tab)

huggingface.co/MaziyarPanahi/Meta-Llama-3.1-405B-Instruct-GGUF (opens in a new tab)

ollama run hf.co/MaziyarPanahi/Meta-Llama-3.1-405B-Instruct-GGUF:Q2_K

Original weights · Hugging Face

Full-precision files from Meta, for fine-tuning, vLLM, Transformers.

huggingface.co/meta-llama/Llama-3.1-405B-Instruct (opens in a new tab)

Free Hugging Face account needed: request access on the model page, and Meta approves it (usually within minutes to a few hours).

Official repo · GitHub

Reference code, inference scripts and docs from Meta. The weights themselves download from Hugging Face.

github.com/meta-llama/llama-models (opens in a new tab)

Meta’s official Llama repo: model cards, prompt formats and download tools.

git clone https://github.com/meta-llama/llama-models

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 50Fair quality (C) · 50 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 6/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q2_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Won't run
How well it runs on the AMD Ryzen AI Max+ 395 (128 GB): speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.6.8 / 45
Memory fitFull marks when the model fits in the share of unified memory the GPU can use; fewer when it goes past that limit.0.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.0.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.0.0 / 15
Match score6.8 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

It doesn’t fit, so only a reduced share of the quality points counts and fit, speed and memory use score zero.

Every quantization on the AMD Ryzen AI Max+ 395 (128 GB)

Quant Memory needed Available Speed Runs Quality Download
Q2_K 175 GB 96.0 GB — Won't run 50Fair quality (C) · 50 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 6/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 9 (opens in a new tab)
Q3_K_M 211 GB 96.0 GB — Won't run 60Good quality (B) · 60 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 8/100 (quality, fit, speed and memory use) sets the ranking. GGUF (Q3_K_S) · part 1 of 9 (opens in a new tab)
Q4_K_M 260 GB 96.0 GB — Won't run 68Good quality (B) · 68 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 9/100 (quality, fit, speed and memory use) sets the ranking.
Q5_K_M 301 GB 96.0 GB — Won't run 69Good quality (B) · 69 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 9/100 (quality, fit, speed and memory use) sets the ranking.
Q6_K 345 GB 96.0 GB — Won't run 71Great quality (A) · 71 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 9/100 (quality, fit, speed and memory use) sets the ranking.
Q8_0 443 GB 96.0 GB — Won't run 72Great quality (A) · 72 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 9/100 (quality, fit, speed and memory use) sets the ranking.
F16 824 GB 96.0 GB — Won't run 72Great quality (A) · 72 of 100: how capable the model is at F16, whatever it runs on. Match score 9/100 (quality, fit, speed and memory use) sets the ranking. Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Hardware that can run it

Models that do run on the AMD Ryzen AI Max+ 395 (128 GB)

Quick answers

How much memory does Llama 3.1 405B Instruct need on the AMD Ryzen AI Max+ 395 128GB?

Even at Q2_K it needs about 175 GB; the AMD Ryzen AI Max+ 395 128GB has 96.0 GB usable.

What can the AMD Ryzen AI Max+ 395 128GB run instead?

Kolibri 1 (78B-A3.5B), Qwen3 Coder Next (80B-A3B) and Qwen3-Next 80B-A3B Thinking run best on it; the page lists more, each with its speed.

What hardware can run Llama 3.1 405B Instruct?

AMD Instinct MI350X 288GB, NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip 252GB and AMD Instinct MI325X 256GB run it; the page lists more, each with its speed.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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