LTX-2.5 (22B, video + audio) on AMD Instinct MI60

Can the AMD Instinct MI60 run LTX-2.5 (22B, video + audio)?

Yes, it runs well (encoder in RAM)

Runs well (encoder in RAM). At Q4 GGUF it needs about 26.8 GB of 32.0 GB usable and takes about 6.2 min per clip.

Best precision: Q4 GGUF
Memory mode: Text encoder offloaded
Time per clip: 6.2 min
Output: 1280×704, 121 frames, 8 steps

Best app to run it on the AMD Instinct MI60

On Linux

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

On Windows

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download LTX-2.5 (22B, video + audio)

Recommended for the AMD Instinct MI60: q4_gguf. Every other precision has its own download link in the table below.

Quantized files · GGUF for ComfyUI

Smaller GGUF versions for ComfyUI (with the ComfyUI-GGUF node). No sign-in needed; the model’s license still applies.

Download the q4_gguf (Q4_K_M) file (opens in a new tab)

huggingface.co/unsloth/LTX-2.5-GGUF (opens in a new tab)

Original weights · Hugging Face

Full-precision files from Lightricks, for fine-tuning, vLLM, Transformers, Diffusers or ComfyUI.

huggingface.co/Lightricks/LTX-2.5 (opens in a new tab)

Free Hugging Face account needed: accept the license on the model page and the download starts right away.

Official repo · GitHub

Reference code, inference scripts and docs from Lightricks. The weights themselves download from Hugging Face.

github.com/Lightricks/LTX-2 (opens in a new tab)

git clone https://github.com/Lightricks/LTX-2

Links checked 2 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 81Great quality (A) · 81 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q4 GGUF, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs wellencoder in RAM: How well it runs on the AMD Instinct MI60: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	36.8 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	20.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	10.4 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	82.3 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every precision on the AMD Instinct MI60

Quant	Memory needed	Available	Speed	Memory mode	Runs	Quality	Download
`FP16`	27.1 GB	32.0 GB	6.4 min	Sequential CPU offload	Runs wellCPU offload	88Excellent quality (A+) · 88 of 100: how capable the model is at FP16, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`FP8`	19.7 GB	32.0 GB	5.8 min	Sequential CPU offload	Runs wellCPU offload	86Excellent quality (A+) · 86 of 100: how capable the model is at FP8, whatever it runs on. Match score 75/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`Q8 GGUF`	20.3 GB	32.0 GB	7.4 min	Sequential CPU offload	Runs wellCPU offload	87Excellent quality (A+) · 87 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 75/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q4 GGUF`	26.8 GB	32.0 GB	6.2 min	Text encoder offloaded	Runs wellencoder in RAM	81Great quality (A) · 81 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)

Other hardware that runs it

88Excellent quality (A+) · 88 of 100: how capable the model is at FP16, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GB10 (128 GB) FP16 · 3.2 min · Runs great
88Excellent quality (A+) · 88 of 100: how capable the model is at FP16, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX Spark N1X (6144-core GPU) (128 GB) FP16 · 3.3 min · Runs great
87Excellent quality (A+) · 87 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell Q8 GGUF · 77 s · Runs great
86Excellent quality (A+) · 86 of 100: how capable the model is at FP8, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking. AMD Ryzen AI Max+ 395 (128 GB) FP8 · 2.6 min · Runs great
88Excellent quality (A+) · 88 of 100: how capable the model is at FP16, whatever it runs on. Match score 87/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) FP16 · 6.6 min · Runs well
81Great quality (A) · 81 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 86/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 5090 Q4 GGUF · 1.6 min · Runs great (encoder in RAM)

Quick answers

How much memory does LTX-2.5 (22B, video + audio) need on the AMD Instinct MI60 32GB?

At Q4 GGUF it needs about 26.8 GB. The AMD Instinct MI60 32GB has 32.0 GB usable.

How long does LTX-2.5 (22B, video + audio) take on the AMD Instinct MI60 32GB?

About 6.2 min per clip at Q4 GGUF and default settings, an estimate scaled from a reference timing by this hardware’s compute speed.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.