MiniCPM-V 4.7 35B-A3B on AMD Instinct MI250X

Can the AMD Instinct MI250X run MiniCPM-V 4.7 35B-A3B?

Yes, it runs great

Runs great. At F16 it needs about 77.6 GB of 128 GB usable, with an estimated speed of 124 tok/s.

Best quant: F16
Generation speed: 124 tok/s
Prompt processing: 19,778 tok/s
First token (1K prompt): 0.3 s
Largest safe context: 256K

Best app to run it on the AMD Instinct MI250X

On Linux

vLLM

Inference server · runs on vLLM

The full model fits in GPU memory at 8-bit, so it can batch many requests: best for serving a team or an app.

vllm serve openbmb/MiniCPM-V-4.7-35B-A3B

Lemonade AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.
LM Studio Point-and-click: search, download and chat in one window.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull openbmb/MiniCPM-V-4.7-35B-A3B-gguf:F16

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

Want an agent? MiniCPM-V 4.7 35B-A3B supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download MiniCPM-V 4.7 35B-A3B

Recommended for the AMD Instinct MI250X: F16. Every other quantization has its own download link in the table below.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the F16 file (opens in a new tab)

huggingface.co/openbmb/MiniCPM-V-4.7-35B-A3B-gguf (opens in a new tab)

ollama run hf.co/openbmb/MiniCPM-V-4.7-35B-A3B-gguf:F16

Original weights · Hugging Face

Full-precision files from OpenBMB, for fine-tuning, vLLM, Transformers.

huggingface.co/openbmb/MiniCPM-V-4.7-35B-A3B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from OpenBMB. The weights themselves download from Hugging Face.

github.com/OpenBMB/MiniCPM-V (opens in a new tab)

git clone https://github.com/OpenBMB/MiniCPM-V

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at F16, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great: How well it runs on the AMD Instinct MI250X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	42.0 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	14.0 / 15
Match score	96.0 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI250X

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	21.3 GB	128 GB	274 tok/s	Runs great	65Good quality (B) · 65 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking.	GGUF files (opens in a new tab)
`Q3_K_M`	24.4 GB	128 GB	256 tok/s	Runs great	78Great quality (A) · 78 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (IQ3_M) (opens in a new tab)
`Q4_K_M`	28.6 GB	128 GB	236 tok/s	Runs great	88Excellent quality (A+) · 88 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 85/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q5_K_M`	32.2 GB	128 GB	220 tok/s	Runs great	90Excellent quality (A+) · 90 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 86/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q6_K`	36.0 GB	128 GB	206 tok/s	Runs great	92Excellent quality (A+) · 92 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 88/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q8_0`	44.5 GB	128 GB	182 tok/s	Runs great	93Excellent quality (A+) · 93 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`F16`	77.6 GB	128 GB	124 tok/s	Runs great	93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell F16 · 98.2 tok/s · Runs great
92Excellent quality (A+) · 92 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. Apple M1 Max (64 GB) Q6_K · 72.3 tok/s · Runs great
92Excellent quality (A+) · 92 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Max (64 GB) Q6_K · 90.1 tok/s · Runs great
90Excellent quality (A+) · 90 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Pro (48 GB) Q5_K_M · 62.2 tok/s · Runs great
92Excellent quality (A+) · 92 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 5090 Q6_K · 179 tok/s · Runs well (tight fit)
93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) F16 · 51.3 tok/s · Runs great

Quick answers

How much memory does MiniCPM-V 4.7 35B-A3B need on the AMD Instinct MI250X 128GB?

At F16 it needs about 77.6 GB. The AMD Instinct MI250X 128GB has 128 GB usable.

How fast is MiniCPM-V 4.7 35B-A3B on the AMD Instinct MI250X 128GB?

About 124 tok/s at F16, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of MiniCPM-V 4.7 35B-A3B should I use on the AMD Instinct MI250X 128GB?

F16. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.