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Can the NVIDIA RTX PRO 5000 Blackwell 72GB run Mistral Medium 3.5 (128B)?

67Good quality (B) · 67 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs well (tight fit)

Runs well (tight fit). At Q3_K_M it needs about 69.7 GB of 72.0 GB usable, with an estimated speed of 16.7 tok/s.

Best quant
Q3_K_M
Generation speed
16.7 tok/s
Prompt processing
366 tok/s
First token (1K prompt)
2.8 s
Largest safe context
14K

Best app to run it on the NVIDIA RTX PRO 5000 Blackwell 72GB

On Windows

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mistral-medium-3.5:128b
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

On Linux

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mistral-medium-3.5:128b
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

Want an agent? Mistral Medium 3.5 (128B) supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Mistral Medium 3.5 (128B)

Recommended for the NVIDIA RTX PRO 5000 Blackwell 72GB: Q3_K_M. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mistral-medium-3.5:128b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q3_K_M files (opens in a new tab)

huggingface.co/unsloth/Mistral-Medium-3.5-128B-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Mistral-Medium-3.5-128B-GGUF

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mistral-Medium-3.5-128B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 67Good quality (B) · 67 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q3_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welltight fit
How well it runs on the NVIDIA RTX PRO 5000 Blackwell 72GB: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.30.4 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.9.7 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score79.1 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the NVIDIA RTX PRO 5000 Blackwell 72GB

Quant Memory needed Available Speed Runs Quality Download
Q2_K 58.2 GB 72.0 GB 21.2 tok/s Runs well 56Good quality (B) · 56 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q3_K_M 69.7 GB 72.0 GB 16.7 tok/s Runs welltight fit 67Good quality (B) · 67 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q4_K_M 85.0 GB 72.0 GB 3.1 tok/s Slowoffloads to RAM 76Great quality (A) · 76 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 63/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q5_K_M 97.8 GB 72.0 GB — Won't run 77Great quality (A) · 77 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q6_K 112 GB 72.0 GB — Won't run 79Great quality (A) · 79 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q8_0 143 GB 72.0 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
F16 263 GB 72.0 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at F16, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Mistral Medium 3.5 (128B) need on the NVIDIA RTX PRO 5000 Blackwell 72GB?

At Q3_K_M it needs about 69.7 GB. The NVIDIA RTX PRO 5000 Blackwell 72GB has 72.0 GB usable.

How fast is Mistral Medium 3.5 (128B) on the NVIDIA RTX PRO 5000 Blackwell 72GB?

About 16.7 tok/s at Q3_K_M, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mistral Medium 3.5 (128B) should I use on the NVIDIA RTX PRO 5000 Blackwell 72GB?

Q3_K_M. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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