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Can the AMD Ryzen AI Max+ 395 (96 GB) run Mistral Medium 3.5 (128B)?

56Good quality (B) · 56 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 69/100 (quality, fit, speed and memory use) sets the ranking.

Yes, but slowly

Slow. At Q2_K it needs about 60.4 GB of 72.0 GB usable, with an estimated speed of 3.5 tok/s.

Best quant
Q2_K
Generation speed
3.5 tok/s
Prompt processing
288 tok/s
First token (1K prompt)
3.6 s
Largest safe context
39K

Best app to run it on the AMD Ryzen AI Max+ 395 (96 GB)

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

  • Built for Ryzen AI and Strix Halo, including NPU + iGPU modes on Windows.
lemonade pull unsloth/Mistral-Medium-3.5-128B-GGUF:Q2_K
  • LM Studio Point-and-click: search, download and chat in one window.
  • Ollama One command with Ollama’s own build of this model.

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

  • Built for Ryzen AI and Strix Halo, including NPU + iGPU modes on Windows.
lemonade pull unsloth/Mistral-Medium-3.5-128B-GGUF:Q2_K
  • LM Studio Point-and-click: search, download and chat in one window.
  • Ollama One command with Ollama’s own build of this model.

Want an agent? Mistral Medium 3.5 (128B) supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Mistral Medium 3.5 (128B)

Recommended for the AMD Ryzen AI Max+ 395 (96 GB): Q2_K. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mistral-medium-3.5:128b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q2_K file (opens in a new tab)

huggingface.co/unsloth/Mistral-Medium-3.5-128B-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Mistral-Medium-3.5-128B-GGUF:Q2_K

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mistral-Medium-3.5-128B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 56Good quality (B) · 56 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 69/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q2_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Slow
How well it runs on the AMD Ryzen AI Max+ 395 (96 GB): speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.25.3 / 45
Memory fitFull marks when the model fits in the share of unified memory the GPU can use; fewer when it goes past that limit.25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.4.4 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score69.8 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Ryzen AI Max+ 395 (96 GB)

Quant Memory needed Available Speed Runs Quality Download
Q2_K 60.4 GB 72.0 GB 3.5 tok/s Slow 56Good quality (B) · 56 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 69/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q3_K_M 71.9 GB 72.0 GB 2.7 tok/s Very slowtight fit 67Good quality (B) · 67 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q4_K_M 87.2 GB 72.0 GB 1.8 tok/s Very slowfar over GPU memory limit 76Great quality (A) · 76 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 56/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q5_K_M 100.0 GB 72.0 GB — Won't run 77Great quality (A) · 77 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q6_K 114 GB 72.0 GB — Won't run 79Great quality (A) · 79 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q8_0 145 GB 72.0 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
F16 265 GB 72.0 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at F16, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Mistral Medium 3.5 (128B) need on the AMD Ryzen AI Max+ 395 96GB?

At Q2_K it needs about 60.4 GB. The AMD Ryzen AI Max+ 395 96GB has 72.0 GB usable.

How fast is Mistral Medium 3.5 (128B) on the AMD Ryzen AI Max+ 395 96GB?

About 3.5 tok/s at Q2_K, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mistral Medium 3.5 (128B) should I use on the AMD Ryzen AI Max+ 395 96GB?

Q2_K. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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