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Can the NVIDIA RTX PRO 6000 Blackwell run Mixtral 8x22B Instruct?

52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs well (tight fit)

Runs well (tight fit). At Q4_K_M it needs about 93.1 GB of 96.0 GB usable, with an estimated speed of 47.4 tok/s.

Best quant
Q4_K_M
Generation speed
47.4 tok/s
Prompt processing
2,308 tok/s
First token (1K prompt)
0.4 s
Largest safe context
20K

Best app to run it on the NVIDIA RTX PRO 6000 Blackwell

On Windows

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mixtral:8x22b-instruct-v0.1-q4_K_M
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

On Linux

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mixtral:8x22b-instruct-v0.1-q4_K_M
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Mixtral 8x22B Instruct

Recommended for the NVIDIA RTX PRO 6000 Blackwell: Q4_K_M. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mixtral:8x22b-instruct-v0.1-q4_K_M

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q4_K_M file (opens in a new tab)

huggingface.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF (opens in a new tab)

ollama run hf.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF:Q4_K_M

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mixtral-8x22B-Instruct-v0.1 (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q4_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welltight fit
How well it runs on the NVIDIA RTX PRO 6000 Blackwell: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.23.5 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score77.5 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the NVIDIA RTX PRO 6000 Blackwell

Quant Memory needed Available Speed Runs Quality Download
Q2_K 63.5 GB 96.0 GB 71.8 tok/s Runs great 38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 72/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 3 (opens in a new tab)
Q3_K_M 76.2 GB 96.0 GB 59.0 tok/s Runs great 46Fair quality (C) · 46 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 75/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 2 (opens in a new tab)
Q4_K_M 93.1 GB 96.0 GB 47.4 tok/s Runs welltight fit 52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 2 (opens in a new tab)
Q5_K_M 107 GB 96.0 GB 11.5 tok/s Runs welloffloads to RAM 53Fair quality (C) · 53 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 57/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 4 (opens in a new tab)
Q6_K 123 GB 96.0 GB — Won't run 54Fair quality (C) · 54 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.
Q8_0 156 GB 96.0 GB — Won't run 55Good quality (B) · 55 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 4 (opens in a new tab)
F16 289 GB 96.0 GB — Won't run 55Good quality (B) · 55 of 100: how capable the model is at F16, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 6 (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Mixtral 8x22B Instruct need on the NVIDIA RTX PRO 6000 Blackwell 96GB?

At Q4_K_M it needs about 93.1 GB. The NVIDIA RTX PRO 6000 Blackwell 96GB has 96.0 GB usable.

How fast is Mixtral 8x22B Instruct on the NVIDIA RTX PRO 6000 Blackwell 96GB?

About 47.4 tok/s at Q4_K_M, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mixtral 8x22B Instruct should I use on the NVIDIA RTX PRO 6000 Blackwell 96GB?

Q4_K_M. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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