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Can the NVIDIA RTX PRO 5000 Blackwell 72GB run Mixtral 8x7B Instruct?

50Fair quality (C) · 50 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs great

Runs great. At Q8_0 it needs about 54.8 GB of 72.0 GB usable, with an estimated speed of 52.2 tok/s.

Best quant
Q8_0
Generation speed
52.2 tok/s
Prompt processing
3,628 tok/s
First token (1K prompt)
0.3 s
Largest safe context
32K

Best app to run it on the NVIDIA RTX PRO 5000 Blackwell 72GB

On Windows

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mixtral:8x7b-instruct-v0.1-q8_0
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

On Linux

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run mixtral:8x7b-instruct-v0.1-q8_0
  • vLLM The full model fits in GPU memory at 8-bit, so it can batch many requests: best for serving a team or an app.
  • LM Studio Point-and-click: search, download and chat in one window.

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Mixtral 8x7B Instruct

Recommended for the NVIDIA RTX PRO 5000 Blackwell 72GB: Q8_0. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mixtral:8x7b-instruct-v0.1-q8_0

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q8_0 file (opens in a new tab)

huggingface.co/TheBloke/Mixtral-8x7B-Instruct-v0.1-GGUF (opens in a new tab)

ollama run hf.co/TheBloke/Mixtral-8x7B-Instruct-v0.1-GGUF:Q8_0

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mixtral-8x7B-Instruct-v0.1 (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 50Fair quality (C) · 50 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q8_0, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great
How well it runs on the NVIDIA RTX PRO 5000 Blackwell 72GB: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.22.5 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score77.5 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the NVIDIA RTX PRO 5000 Blackwell 72GB

Quant Memory needed Available Speed Runs Quality Download
Q2_K 24.0 GB 72.0 GB 127 tok/s Runs great 35Basic quality (D) · 35 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 63/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q3_K_M 28.2 GB 72.0 GB 108 tok/s Runs great 42Fair quality (C) · 42 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 67/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q4_K_M 33.8 GB 72.0 GB 89.4 tok/s Runs great 47Fair quality (C) · 47 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 72/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q5_K_M 38.4 GB 72.0 GB 77.1 tok/s Runs great 48Fair quality (C) · 48 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q6_K 43.6 GB 72.0 GB 67.2 tok/s Runs great 49Fair quality (C) · 49 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
Q8_0 54.8 GB 72.0 GB 52.2 tok/s Runs great 50Fair quality (C) · 50 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking. GGUF (opens in a new tab)
F16 98.7 GB 72.0 GB — Won't run 50Fair quality (C) · 50 of 100: how capable the model is at F16, whatever it runs on. Match score 6/100 (quality, fit, speed and memory use) sets the ranking. Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Mixtral 8x7B Instruct need on the NVIDIA RTX PRO 5000 Blackwell 72GB?

At Q8_0 it needs about 54.8 GB. The NVIDIA RTX PRO 5000 Blackwell 72GB has 72.0 GB usable.

How fast is Mixtral 8x7B Instruct on the NVIDIA RTX PRO 5000 Blackwell 72GB?

About 52.2 tok/s at Q8_0, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mixtral 8x7B Instruct should I use on the NVIDIA RTX PRO 5000 Blackwell 72GB?

Q8_0. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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