Qwen2.5-VL 72B Instruct on AMD Ryzen AI Max+ PRO 495 (192 GB)

Can the AMD Ryzen AI Max+ PRO 495 (192 GB) run Qwen2.5-VL 72B Instruct?

Yes, but slowly

Slow. At Q5_K_M it needs about 68.2 GB of 159 GB usable, with an estimated speed of 3.2 tok/s.

Best quant: Q5_K_M
Generation speed: 3.2 tok/s
Prompt processing: 519 tok/s
First token (1K prompt): 2.0 s
Largest safe context: 125K

Best app to run it on the AMD Ryzen AI Max+ PRO 495 (192 GB)

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

Built for Ryzen AI and Strix Halo, including NPU + iGPU modes on Windows.

lemonade pull unsloth/Qwen2.5-VL-72B-Instruct-GGUF:Q5_K_M

LM Studio Point-and-click: search, download and chat in one window.
Ollama One command with Ollama’s own build of this model.

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

Built for Ryzen AI and Strix Halo, including NPU + iGPU modes on Windows.

lemonade pull unsloth/Qwen2.5-VL-72B-Instruct-GGUF:Q5_K_M

LM Studio Point-and-click: search, download and chat in one window.
Ollama One command with Ollama’s own build of this model.

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Qwen2.5-VL 72B Instruct

Recommended for the AMD Ryzen AI Max+ PRO 495 (192 GB): Q5_K_M. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run qwen2.5vl:72b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q5_K_M files (opens in a new tab)

huggingface.co/unsloth/Qwen2.5-VL-72B-Instruct-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Qwen2.5-VL-72B-Instruct-GGUF

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers.

huggingface.co/Qwen/Qwen2.5-VL-72B-Instruct (opens in a new tab)

No sign-in needed.

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 70Great quality (A) · 70 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q5_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Slow: How well it runs on the AMD Ryzen AI Max+ PRO 495 (192 GB): speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	31.9 / 45
Memory fitFull marks when the model fits in the share of unified memory the GPU can use; fewer when it goes past that limit.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	4.3 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	9.9 / 15
Match score	71.0 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Ryzen AI Max+ PRO 495 (192 GB)

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	45.4 GB	159 GB	6.5 tok/s	Slow	51Fair quality (C) · 51 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 60/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q3_K_M`	52.0 GB	159 GB	5.1 tok/s	Slow	61Good quality (B) · 61 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 65/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q4_K_M`	60.8 GB	159 GB	3.9 tok/s	Slow	69Good quality (B) · 69 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 69/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q5_K_M`	68.2 GB	159 GB	3.2 tok/s	Slow	70Great quality (A) · 70 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q6_K`	76.2 GB	159 GB	2.7 tok/s	Very slow	72Great quality (A) · 72 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 72/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q8_0`	93.8 GB	159 GB	2.0 tok/s	Very slow	73Great quality (A) · 73 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (UD-Q8_K_XL) · folder (opens in a new tab)
`F16`	163 GB	159 GB	0.8 tok/s	Very slowover GPU memory limit	73Great quality (A) · 73 of 100: how capable the model is at F16, whatever it runs on. Match score 59/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

69Good quality (B) · 69 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell Q4_K_M · 30.0 tok/s · Runs well
61Good quality (B) · 61 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Max (64 GB) Q3_K_M · 10.2 tok/s · Runs well (tight fit)
69Good quality (B) · 69 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) Q4_K_M · 11.5 tok/s · Runs well
69Good quality (B) · 69 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (256 GB) Q4_K_M · 11.8 tok/s · Runs well
61Good quality (B) · 61 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Max (128 GB) Q3_K_M · 10.2 tok/s · Runs well
69Good quality (B) · 69 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 69/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (512 GB) Q4_K_M · 11.8 tok/s · Runs well

Quick answers

How much memory does Qwen2.5-VL 72B Instruct need on the AMD Ryzen AI Max+ PRO 495 192GB?

At Q5_K_M it needs about 68.2 GB. The AMD Ryzen AI Max+ PRO 495 192GB has 159 GB usable.

How fast is Qwen2.5-VL 72B Instruct on the AMD Ryzen AI Max+ PRO 495 192GB?

About 3.2 tok/s at Q5_K_M, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Qwen2.5-VL 72B Instruct should I use on the AMD Ryzen AI Max+ PRO 495 192GB?

Q5_K_M. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.