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Can the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip run Qwen3-VL 235B-A22B Instruct?

88Excellent quality (A+) · 88 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs great

Runs great. At Q6_K it needs about 208 GB of 252 GB usable, with an estimated speed of 138 tok/s.

Best quant
Q6_K
Generation speed
138 tok/s
Prompt processing
2,618 tok/s
First token (1K prompt)
0.4 s
Largest safe context
231K

Best app to run it on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip

On Windows

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run qwen3-vl:235b
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

On Linux

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

  • One command with Ollama’s own build of this model.
  • Serves an OpenAI-compatible API that other apps and coding tools can use.
ollama run qwen3-vl:235b
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

Want an agent? Qwen3-VL 235B-A22B Instruct supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Qwen3-VL 235B-A22B Instruct

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run qwen3-vl:235b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

huggingface.co/Qwen/Qwen3-VL-235B-A22B-Instruct-GGUF (opens in a new tab)

ollama run hf.co/Qwen/Qwen3-VL-235B-A22B-Instruct-GGUF

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers.

huggingface.co/Qwen/Qwen3-VL-235B-A22B-Instruct (opens in a new tab)

No sign-in needed.

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 88Excellent quality (A+) · 88 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q6_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great
How well it runs on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.39.6 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score94.6 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip

Quant Memory needed Available Speed Runs Quality Download
Q2_K 109 GB 252 GB 215 tok/s Runs great 62Good quality (B) · 62 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking. GGUF files (opens in a new tab)
Q3_K_M 130 GB 252 GB 193 tok/s Runs great 74Great quality (A) · 74 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 85/100 (quality, fit, speed and memory use) sets the ranking. GGUF files (opens in a new tab)
Q4_K_M 159 GB 252 GB 170 tok/s Runs great 84Great quality (A) · 84 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 92/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 3 (opens in a new tab)
Q5_K_M 182 GB 252 GB 153 tok/s Runs great 86Excellent quality (A+) · 86 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 93/100 (quality, fit, speed and memory use) sets the ranking. GGUF files (opens in a new tab)
Q6_K 208 GB 252 GB 138 tok/s Runs great 88Excellent quality (A+) · 88 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking. GGUF files (opens in a new tab)
Q8_0 265 GB 252 GB 28.5 tok/s Runs welloffloads to RAM 89Excellent quality (A+) · 89 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 6 (opens in a new tab)
F16 486 GB 252 GB — Won't run 89Excellent quality (A+) · 89 of 100: how capable the model is at F16, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 10 (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Qwen3-VL 235B-A22B Instruct need on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip 252GB?

At Q6_K it needs about 208 GB. The NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip 252GB has 252 GB usable.

How fast is Qwen3-VL 235B-A22B Instruct on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip 252GB?

About 138 tok/s at Q6_K, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Qwen3-VL 235B-A22B Instruct should I use on the NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip 252GB?

Q6_K. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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