Can the AMD Instinct MI100 run Qwen3.8 27B?

Yes, it runs great

Runs great. At Q5_K_M it needs about 22.5 GB of 32.0 GB usable, with an estimated speed of 38.6 tok/s.

Best quant: Q5_K_M
Generation speed: 38.6 tok/s
Prompt processing: 1,029 tok/s
First token (1K prompt): 1.0 s
Largest safe context: 150K

Best app to run it on the AMD Instinct MI100

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull unsloth/Qwen3.8-27B-GGUF:Q5_K_M

LM Studio Point-and-click: search, download and chat in one window.
Ollama One command with Ollama’s own build of this model.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull unsloth/Qwen3.8-27B-GGUF:Q5_K_M

LM Studio Point-and-click: search, download and chat in one window.
Ollama One command with Ollama’s own build of this model.

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Qwen3.8 27B

Recommended for the AMD Instinct MI100: Q5_K_M. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run qwen3.8:27b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q5_K_M file (opens in a new tab)

huggingface.co/unsloth/Qwen3.8-27B-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Qwen3.8-27B-GGUF:Q5_K_M

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers.

huggingface.co/Qwen/Qwen3.8-27B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Alibaba. The weights themselves download from Hugging Face.

github.com/QwenLM/Qwen3.8 (opens in a new tab)

Qwen’s current repo: Qwen3.5 and Qwen3.6 redirect here.

git clone https://github.com/QwenLM/Qwen3.8

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 92Excellent quality (A+) · 92 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q5_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great: How well it runs on the AMD Instinct MI100: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	41.7 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	14.7 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	96.4 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI100

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	13.8 GB	32.0 GB	76.8 tok/s	Runs great	66Good quality (B) · 66 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (UD-Q2_K_XL) (opens in a new tab)
`Q3_K_M`	16.3 GB	32.0 GB	60.5 tok/s	Runs great	80Great quality (A) · 80 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 87/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (UD-Q3_K_XL) (opens in a new tab)
`Q4_K_M`	19.7 GB	32.0 GB	46.8 tok/s	Runs great	90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q5_K_M`	22.5 GB	32.0 GB	38.6 tok/s	Runs great	92Excellent quality (A+) · 92 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q6_K`	25.5 GB	32.0 GB	32.4 tok/s	Runs great	94Excellent quality (A+) · 94 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q8_0`	32.2 GB	32.0 GB	21.8 tok/s	Runs welloffloads to RAM	95Excellent quality (A+) · 95 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`F16`	58.3 GB	32.0 GB	—	Won't run	95Excellent quality (A+) · 95 of 100: how capable the model is at F16, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

94Excellent quality (A+) · 94 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 5090 Q6_K · 54.9 tok/s · Runs great
90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 3090 Q4_K_M · 41.4 tok/s · Runs great
90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 4090 Q4_K_M · 44.5 tok/s · Runs great
90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. AMD Radeon RX 7900 XTX Q4_K_M · 36.5 tok/s · Runs great
95Excellent quality (A+) · 95 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell Q8_0 · 40.3 tok/s · Runs great
80Great quality (A) · 80 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GeForce RTX 4080 SUPER Q3_K_M · 42.0 tok/s · Runs well (tight fit)

Quick answers

How much memory does Qwen3.8 27B need on the AMD Instinct MI100 32GB?

At Q5_K_M it needs about 22.5 GB. The AMD Instinct MI100 32GB has 32.0 GB usable.

How fast is Qwen3.8 27B on the AMD Instinct MI100 32GB?

About 38.6 tok/s at Q5_K_M, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Qwen3.8 27B should I use on the AMD Instinct MI100 32GB?

Q5_K_M. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.