Wan 2.2 S2V 14B (speech to video) on NVIDIA RTX PRO 4000 Blackwell

Can the NVIDIA RTX PRO 4000 Blackwell run Wan 2.2 S2V 14B (speech to video)?

Yes, but slowly (tight fit)

Slow (tight fit). At Q4 GGUF it needs about 21.6 GB of 24.0 GB usable and takes about 34.5 min per clip.

Best precision: Q4 GGUF
Memory mode: Everything on GPU
Time per clip: 34.5 min
Output: 832×480, 81 frames, 40 steps

Best app to run it on the NVIDIA RTX PRO 4000 Blackwell

On Windows

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

On Linux

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Wan 2.2 S2V 14B (speech to video)

Recommended for the NVIDIA RTX PRO 4000 Blackwell: q4_gguf. Every other precision has its own download link in the table below.

Quantized files · GGUF for ComfyUI

Smaller GGUF versions for ComfyUI (with the ComfyUI-GGUF node). No sign-in needed; the model’s license still applies.

Download the q4_gguf (Q4_K_S) file (opens in a new tab)

huggingface.co/QuantStack/Wan2.2-S2V-14B-GGUF (opens in a new tab)

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers, Diffusers or ComfyUI.

huggingface.co/Wan-AI/Wan2.2-S2V-14B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Alibaba. The weights themselves download from Hugging Face.

github.com/Wan-Video/Wan2.2 (opens in a new tab)

git clone https://github.com/Wan-Video/Wan2.2

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 70Great quality (A) · 70 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q4 GGUF, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Slowtight fit: How well it runs on the NVIDIA RTX PRO 4000 Blackwell: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	31.8 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	23.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	4.4 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	74.2 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every precision on the NVIDIA RTX PRO 4000 Blackwell

Quant	Memory needed	Available	Speed	Memory mode	Runs	Quality	Download
`FP16`	17.0 GB	24.0 GB	37.3 min	Sequential CPU offload	SlowCPU offload	76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 65/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`FP8`	22.1 GB	24.0 GB	27.1 min	Text encoder offloaded	Slowtight fit · encoder in RAM	74Great quality (A) · 74 of 100: how capable the model is at FP8, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`Q8 GGUF`	11.7 GB	24.0 GB	42.9 min	Sequential CPU offload	Very slowCPU offload	75Great quality (A) · 75 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 61/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q4 GGUF`	21.6 GB	24.0 GB	34.5 min	Everything on GPU	Slowtight fit	70Great quality (A) · 70 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)

Other hardware that runs it

74Great quality (A) · 74 of 100: how capable the model is at FP8, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell FP8 · 11.0 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H100 80GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H800 80GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GH200 Grace Hopper (96 GB GPU) FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 75/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H200 141GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA B200 FP16 · 10.2 min · Runs well

Quick answers

How much memory does Wan 2.2 S2V 14B (speech to video) need on the NVIDIA RTX PRO 4000 Blackwell 24GB?

At Q4 GGUF it needs about 21.6 GB. The NVIDIA RTX PRO 4000 Blackwell 24GB has 24.0 GB usable.

How long does Wan 2.2 S2V 14B (speech to video) take on the NVIDIA RTX PRO 4000 Blackwell 24GB?

About 34.5 min per clip at Q4 GGUF and default settings, an estimate scaled from a reference timing by this hardware’s compute speed.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.