Wan 2.2 S2V 14B (speech to video) on AMD Ryzen AI Max 385 (64 GB)

Can the AMD Ryzen AI Max 385 (64 GB) run Wan 2.2 S2V 14B (speech to video)?

Yes, but slowly

Slow. At FP8 it needs about 28.1 GB of 48.0 GB usable and takes about 35.0 min per clip.

Best precision: FP8
Memory mode: Everything on GPU
Time per clip: 35.0 min
Output: 832×480, 81 frames, 40 steps

Best app to run it on the AMD Ryzen AI Max 385 (64 GB)

On Windows

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

On Linux

ComfyUI

Desktop app · runs on PyTorch (ComfyUI), GGUF via ComfyUI-GGUF

Runs this model with built-in or popular custom nodes; GGUF files load with ComfyUI-GGUF.

Get ComfyUI

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Wan 2.2 S2V 14B (speech to video)

Quantized files · GGUF for ComfyUI

Smaller GGUF versions for ComfyUI (with the ComfyUI-GGUF node). No sign-in needed; the model’s license still applies.

huggingface.co/QuantStack/Wan2.2-S2V-14B-GGUF (opens in a new tab)

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers, Diffusers or ComfyUI.

huggingface.co/Wan-AI/Wan2.2-S2V-14B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Alibaba. The weights themselves download from Hugging Face.

github.com/Wan-Video/Wan2.2 (opens in a new tab)

git clone https://github.com/Wan-Video/Wan2.2

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 74Great quality (A) · 74 of 100: how capable the model is at FP8, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at FP8, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Slow: How well it runs on the AMD Ryzen AI Max 385 (64 GB): speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	33.5 / 45
Memory fitFull marks when the model fits in the share of unified memory the GPU can use; fewer when it goes past that limit.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	4.4 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	13.5 / 15
Match score	76.4 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every precision on the AMD Ryzen AI Max 385 (64 GB)

Quant	Memory needed	Available	Speed	Memory mode	Runs	Quality	Download
`FP16`	38.4 GB	48.0 GB	40.8 min	Text encoder offloaded	Very slowencoder unloaded after use	76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`FP8`	28.1 GB	48.0 GB	35.0 min	Everything on GPU	Slow	74Great quality (A) · 74 of 100: how capable the model is at FP8, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)
`Q8 GGUF`	29.3 GB	48.0 GB	44.7 min	Everything on GPU	Very slow	75Great quality (A) · 75 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)
`Q4 GGUF`	21.6 GB	48.0 GB	46.6 min	Everything on GPU	Very slow	70Great quality (A) · 70 of 100: how capable the model is at Q4 GGUF, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking.	GGUF (opens in a new tab)

Other hardware that runs it

74Great quality (A) · 74 of 100: how capable the model is at FP8, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell FP8 · 11.0 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H100 80GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H800 80GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GH200 Grace Hopper (96 GB GPU) FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 75/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H200 141GB SXM FP16 · 11.6 min · Runs well
76Great quality (A) · 76 of 100: how capable the model is at FP16, whatever it runs on. Match score 73/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA B200 FP16 · 10.2 min · Runs well

Quick answers

How much memory does Wan 2.2 S2V 14B (speech to video) need on the AMD Ryzen AI Max 385 64GB?

At FP8 it needs about 28.1 GB. The AMD Ryzen AI Max 385 64GB has 48.0 GB usable.

How long does Wan 2.2 S2V 14B (speech to video) take on the AMD Ryzen AI Max 385 64GB?

About 35.0 min per clip at FP8 and default settings, an estimate scaled from a reference timing by this hardware’s compute speed.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.