What AI models can the AMD R-Series RX-421ND NAS (64 GB) run?

RAM: 64.0 GB
Usable for models: 54.4 GB
Memory bandwidth: 19 GB/s
Runs models on: CPU cores
Released: 2016

519 / 621 LLMs run Best: Nanbeige4.3 33B 61 / 61 Image models run Best: Krea 2 Turbo 42 / 43 Video models run Best: LTX-2.3 69 / 70 Decision models run Best: Qwen3 Reranker 4B

A NAS with this chip runs models on its processor cores, so memory speed sets the pace: small models (about 1-4B) answer at a usable speed, bigger ones are slow. We plan around 54.4 GB for models, what is left after the NAS system and its storage services. Models run in a container (Docker) or the maker’s app store, and speeds assume the NAS isn’t busy with storage work.

More about this hardware

Maker	AMD
Type	NAS (network attached storage) processor
Share of memory for models	85% (what the NAS system and its storage services typically leave free at this size)
Chip	AMD R-Series RX-421ND
AI accelerator	None. Models run on the processor cores.
NAS models with this chip	QNAP TS-473 · QNAP TS-673 · QNAP TS-873
Memory type	System RAM, shared with the NAS operating system and its storage services
Bandwidth figure	19.2 GB/s, estimated, see the note below
Note	One profile for every NAS built on this chip. Memory speed is an estimate from the chip’s supported memory in a typical NAS fitting; a unit with one memory module runs slower than one with two. Speed assumes the NAS is not busy with storage work.
Specifications	www.qnap.com

Apps that run models well on the AMD R-Series RX-421ND NAS (64 GB)

Linux

For a typical model that fits in memory. Each model page picks the best app for that model on this hardware. All apps

3 products with the AMD R-Series RX-421ND NAS (64 GB)

TS-473QNAP · NAS · 4, 8 or 64 GBProduct page (opens in a new tab)Discontinued
TS-673QNAP · NAS · 4, 8 or 64 GBProduct page (opens in a new tab)Discontinued
TS-873QNAP · NAS · 4, 8 or 64 GBProduct page (opens in a new tab)Discontinued

Best LLMs for the AMD R-Series RX-421ND NAS (64 GB)

Quality	Model	Quant	Memory	Speed	Runs
95Excellent quality (A+) · 95 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 83/100 (quality, fit, speed and memory use) sets the ranking.	Nanbeige4.3 33BBOSS Zhipin (Nanbeige)	`Q8_0`	41.8 GB	0.1 tok/s	Very slow
95Excellent quality (A+) · 95 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 83/100 (quality, fit, speed and memory use) sets the ranking.	Qwen3.8 27BAlibaba	`Q8_0`	34.9 GB	0.1 tok/s	Very slow
94Excellent quality (A+) · 94 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 83/100 (quality, fit, speed and memory use) sets the ranking.	Qwen3.6 27BAlibaba	`Q8_0`	34.9 GB	0.1 tok/s	Very slow
93Excellent quality (A+) · 93 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking.	Qwen3.5 27BAlibaba	`Q8_0`	34.9 GB	0.1 tok/s	Very slow
92Excellent quality (A+) · 92 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking.	Muse Glimmer 30BMeta	`Q8_0`	36.6 GB	0.1 tok/s	Very slow
91Excellent quality (A+) · 91 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking.	Gemma 4 31BGoogle	`Q8_0`	39.7 GB	0.1 tok/s	Very slow
90Excellent quality (A+) · 90 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking.	TMax 27BAi2	`Q8_0`	34.5 GB	0.2 tok/s	Very slow
87Excellent quality (A+) · 87 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Nemotron 3.5 Bolt 74B-A9BNVIDIA	`Q4_K_M`	50.7 GB	0.9 tok/s	Very slowtight fit
85Excellent quality (A+) · 85 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Flint (40B-A2.5B)Recursive	`Q4_K_M`	29.5 GB	3.2 tok/s	Slow
88Excellent quality (A+) · 88 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Fara 1.5 27BMicrosoft	`Q8_0`	34.5 GB	0.2 tok/s	Very slow
86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	UI-Mate 27BTencent	`Q8_0`	34.5 GB	0.2 tok/s	Very slow
76Great quality (A) · 76 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	Kolibri 1 (78B-A3.5B)Aleph Alpha	`Q3_K_M`	43.4 GB	3.0 tok/s	Slow

Best Image models for the AMD R-Series RX-421ND NAS (64 GB)

Quality	Model	Quant	Memory	Speed	Runs
92Excellent quality (A+) · 92 of 100: how capable the model is at FP16, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking.	Krea 2 TurboKrea	`FP16`	37.4 GB	24.3 min	Very slow
92Excellent quality (A+) · 92 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking.	Qwen-Image 2.1Alibaba	`Q8 GGUF`	41.6 GB	6.5 h	Very slow
89Excellent quality (A+) · 89 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Qwen-Image 2512Alibaba	`Q8 GGUF`	36.5 GB	9.7 h	Very slow
84Great quality (A) · 84 of 100: how capable the model is at FP16, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	FLUX.2 [klein] 9BBlack Forest Labs	`FP16`	37.1 GB	10.2 min	Very slow
88Excellent quality (A+) · 88 of 100: how capable the model is at FP16, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	ERNIE-ImageBaidu	`FP16`	34.0 GB	2.1 h	Very slow
93Excellent quality (A+) · 93 of 100: how capable the model is at FP16, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	Fibo 2.0 DevBria AI	`FP16`	27.7 GB	2.1 h	Very slow

Best Video models for the AMD R-Series RX-421ND NAS (64 GB)

Quality	Model	Quant	Memory	Speed	Runs
85Excellent quality (A+) · 85 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	LTX-2.3Lightricks	`Q8 GGUF`	45.6 GB	43.3 h	Very slow
85Excellent quality (A+) · 85 of 100: how capable the model is at FP16, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	Bernini-R A14B (video generation + editing)ByteDance	`FP16`	46.0 GB	67.8 h	Very slow
85Excellent quality (A+) · 85 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	Wan 2.2 I2V A14BAlibaba	`Q8 GGUF`	39.3 GB	173.3 h	Very slow
85Excellent quality (A+) · 85 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	Wan 2.2 T2V A14BAlibaba	`Q8 GGUF`	39.3 GB	173.3 h	Very slow
87Excellent quality (A+) · 87 of 100: how capable the model is at Q8 GGUF, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	LTX-2.5 (22B, video + audio)Lightricks	`Q8 GGUF`	49.8 GB	9.9 h	Very slowtight fit

Best Decision models for the AMD R-Series RX-421ND NAS (64 GB)

Quality	Model	Quant	Memory	Speed	Runs
90Excellent quality (A+) · 90 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Qwen3 Reranker 4BAlibaba	`Q8_0`	9.5 GB	138.2 s	Very slow
90Excellent quality (A+) · 90 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Qwen3 Reranker 8BAlibaba	`Q8_0`	13.9 GB	281.5 s	Very slow
90Excellent quality (A+) · 90 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	Skywork Reward V2 Llama 3.1 8BSkywork	`Q8_0`	10.4 GB	556.5 s	Very slow
88Excellent quality (A+) · 88 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 80/100 (quality, fit, speed and memory use) sets the ranking.	zerank-2ZeroEntropy	`Q8_0`	9.5 GB	138.2 s	Very slow
86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	Jina Reranker v3.5Jina AI	`Q8_0`	5.8 GB	20.6 s	Very slow
86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 79/100 (quality, fit, speed and memory use) sets the ranking.	Shieldstral 1.0 3BMistral AI	`Q8_0`	9.3 GB	132.3 s	Very slow
86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	GLiDE 27BFastino	`Q8_0`	34.8 GB	484.0 s	Very slow
84Great quality (A) · 84 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking.	Jina Reranker v3Jina AI	`Q8_0`	5.8 GB	20.6 s	Very slow

Best LLMs by task on this hardware Open in Model Finder

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.