Best local LLMs for the AMD Instinct MI250X

Each list assumes the context that task needs, so a model that fits for chat may rank lower for long documents.

General chat at 8K context

  1. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Super VL 120B-A12B Q4_K_M · 146 tok/s · Runs great
  2. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 122B-A10B Q6_K · 129 tok/s · Runs well (tight fit)
  3. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.5 122B-A10B Q5_K_M · 143 tok/s · Runs great
  4. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q4_K_M · 196 tok/s · Runs well (tight fit)
  5. 90Excellent quality (A+) · 90 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 35B-A3B F16 · 124 tok/s · Runs great

Coding at 32K context

  1. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Super VL 120B-A12B Q4_K_M · 146 tok/s · Runs great
  2. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 122B-A10B Q6_K · 129 tok/s · Runs well (tight fit)
  3. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.5 122B-A10B Q5_K_M · 143 tok/s · Runs great
  4. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q4_K_M · 196 tok/s · Runs well (tight fit)
  5. 91Excellent quality (A+) · 91 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. KAT-Coder V2.5 Dev (35B-A3B) F16 · 124 tok/s · Runs great

Reasoning at 32K context

  1. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Super VL 120B-A12B Q4_K_M · 146 tok/s · Runs great
  2. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 122B-A10B Q6_K · 129 tok/s · Runs well (tight fit)
  3. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.5 122B-A10B Q5_K_M · 143 tok/s · Runs great
  4. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q4_K_M · 196 tok/s · Runs well (tight fit)
  5. 91Excellent quality (A+) · 91 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. KAT-Coder V2.5 Dev (35B-A3B) F16 · 124 tok/s · Runs great

Documents (RAG) at 32K context

  1. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Super VL 120B-A12B Q4_K_M · 146 tok/s · Runs great
  2. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.5 122B-A10B Q5_K_M · 143 tok/s · Runs great
  3. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q4_K_M · 196 tok/s · Runs well (tight fit)
  4. 90Excellent quality (A+) · 90 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 35B-A3B F16 · 124 tok/s · Runs great
  5. 89Excellent quality (A+) · 89 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. Apodex 1.1 Mini (35B-A3B) F16 · 124 tok/s · Runs great

Agents & tools at 64K context

  1. 92Excellent quality (A+) · 92 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Super VL 120B-A12B Q6_K · 116 tok/s · Runs well (tight fit)
  2. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Ornith 1.5 122B-A10B Q6_K · 129 tok/s · Runs well (tight fit)
  3. 89Excellent quality (A+) · 89 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.5 122B-A10B Q5_K_M · 143 tok/s · Runs great
  4. 91Excellent quality (A+) · 91 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 100/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.8 Flash Next (125B-A6B) Q4_K_M · 196 tok/s · Runs well (tight fit)
  5. 91Excellent quality (A+) · 91 of 100: how capable the model is at F16, whatever it runs on. Match score 99/100 (quality, fit, speed and memory use) sets the ranking. KAT-Coder V2.5 Dev (35B-A3B) F16 · 124 tok/s · Runs great

Reverse engineering at 32K context

  1. 88Excellent quality (A+) · 88 of 100: how capable the model is at F16, whatever it runs on. Match score 97/100 (quality, fit, speed and memory use) sets the ranking. GLM-4.7 Flash (30B-A3B) F16 · 124 tok/s · Runs great
  2. 92Excellent quality (A+) · 92 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. Nemotron 3.5 Bolt 74B-A9B Q8_0 · 112 tok/s · Runs great
  3. 93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. Qwen3.6 35B-A3B F16 · 124 tok/s · Runs great
  4. 84Great quality (A) · 84 of 100: how capable the model is at MXFP4, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. gpt-oss 120B MXFP4 · 211 tok/s · Runs great
  5. 93Excellent quality (A+) · 93 of 100: how capable the model is at F16, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. MiniCPM-V 4.7 35B-A3B F16 · 124 tok/s · Runs great

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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