Mixtral 8x22B Instruct on AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB)

Can the AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB) run Mixtral 8x22B Instruct?

Yes, but slowly (tight fit)

Slow (tight fit). At Q2_K it needs about 64.5 GB of 72.0 GB usable, with an estimated speed of 4.8 tok/s.

Best quant: Q2_K
Generation speed: 4.8 tok/s
Prompt processing: 458 tok/s
First token (1K prompt): 2.2 s
Largest safe context: 39K

Best app to run it on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB)

On Linux

Ollama

Command line + local API · runs on llama.cpp (ggml), MLX (Apple silicon, preview)

One command with Ollama’s own build of this model.
Serves an OpenAI-compatible API that other apps and coding tools can use.

ollama run mixtral:8x22b-instruct-v0.1-q2_K

llama.cpp Usually the first to support new model architectures.
KoboldCpp

How we choose: the files published for this model, which apps run in a container on a NAS without a graphics card (models run on its processor), and whether the model fits fully in the memory models can use. Details.

Download Mixtral 8x22B Instruct

Recommended for the AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB): Q2_K. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mixtral:8x22b-instruct-v0.1-q2_K

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q2_K file (opens in a new tab)

huggingface.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF (opens in a new tab)

ollama run hf.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF:Q2_K

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mixtral-8x22B-Instruct-v0.1 (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 61/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q2_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Slowtight fit: How well it runs on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB): speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	17.3 / 45
Memory fitFull marks when the model fits in the share of the NAS’s memory that models can use (the rest stays with the NAS system and its storage services); fewer when it goes past that limit.	24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	5.2 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	61.5 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS (96 GB)

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	64.5 GB	72.0 GB	4.8 tok/s	Slowtight fit	38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 61/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 3 (opens in a new tab)
`Q3_K_M`	77.1 GB	72.0 GB	3.2 tok/s	Slowover GPU memory limit	46Fair quality (C) · 46 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 50/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 2 (opens in a new tab)
`Q4_K_M`	94.0 GB	72.0 GB	—	Won't run	52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 2 (opens in a new tab)
`Q5_K_M`	108 GB	72.0 GB	—	Won't run	53Fair quality (C) · 53 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 4 (opens in a new tab)
`Q6_K`	124 GB	72.0 GB	—	Won't run	54Fair quality (C) · 54 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.
`Q8_0`	157 GB	72.0 GB	—	Won't run	55Good quality (B) · 55 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 4 (opens in a new tab)
`F16`	289 GB	72.0 GB	—	Won't run	55Good quality (B) · 55 of 100: how capable the model is at F16, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · part 1 of 6 (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 77/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX PRO 6000 Blackwell Q4_K_M · 47.4 tok/s · Runs well (tight fit)
52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 74/100 (quality, fit, speed and memory use) sets the ranking. Apple M2 Ultra (192 GB) Q4_K_M · 20.2 tok/s · Runs well
52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (256 GB) Q4_K_M · 20.7 tok/s · Runs well
52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 71/100 (quality, fit, speed and memory use) sets the ranking. Apple M4 Max (128 GB) Q4_K_M · 14.1 tok/s · Runs well (tight fit)
46Fair quality (C) · 46 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 68/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA RTX Spark N1X (6144-core GPU) (128 GB) Q3_K_M · 11.7 tok/s · Runs well
46Fair quality (C) · 46 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 68/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GB10 (128 GB) Q3_K_M · 10.7 tok/s · Runs well

Quick answers

How much memory does Mixtral 8x22B Instruct need on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS 96GB?

At Q2_K it needs about 64.5 GB. The AMD Ryzen AI 9 HX PRO 370 / 375 NAS 96GB has 72.0 GB usable.

How fast is Mixtral 8x22B Instruct on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS 96GB?

About 4.8 tok/s at Q2_K, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mixtral 8x22B Instruct should I use on the AMD Ryzen AI 9 HX PRO 370 / 375 NAS 96GB?

Q2_K. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.