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Can the NVIDIA Quadro RTX 8000 run Mixtral 8x22B Instruct?

38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 50/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs well (offloads to RAM)

Runs well (offloads to RAM). At Q2_K it needs about 61.1 GB of 48.0 GB usable, with an estimated speed of 10.8 tok/s.

Best quant
Q2_K
Generation speed
10.8 tok/s
Prompt processing
252 tok/s
First token (1K prompt)
4.1 s
Largest safe context
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Best app to run it on the NVIDIA Quadro RTX 8000

On Windows

LM Studio

Desktop app · runs on llama.cpp, MLX

  • Splits the model between GPU memory and system RAM, which this setup needs.
  • Point-and-click: search, download and chat in one window.

Open Mixtral 8x22B Instruct in LM Studio

  • Ollama Splits the model between GPU memory and system RAM, which this setup needs.
  • llama.cpp Splits the model between GPU memory and system RAM, which this setup needs.

On Linux

LM Studio

Desktop app · runs on llama.cpp, MLX

  • Splits the model between GPU memory and system RAM, which this setup needs.
  • Point-and-click: search, download and chat in one window.

Open Mixtral 8x22B Instruct in LM Studio

  • Ollama Splits the model between GPU memory and system RAM, which this setup needs.
  • llama.cpp Splits the model between GPU memory and system RAM, which this setup needs.

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Mixtral 8x22B Instruct

Recommended for the NVIDIA Quadro RTX 8000: Q2_K. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run mixtral:8x22b-instruct-v0.1-q2_K

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q2_K file (opens in a new tab)

huggingface.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF (opens in a new tab)

ollama run hf.co/MaziyarPanahi/Mixtral-8x22B-Instruct-v0.1-GGUF:Q2_K

Original weights · Hugging Face

Full-precision files from Mistral AI, for fine-tuning, vLLM, Transformers.

huggingface.co/mistralai/Mixtral-8x22B-Instruct-v0.1 (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Mistral AI. The weights themselves download from Hugging Face.

github.com/mistralai/mistral-inference (opens in a new tab)

Mistral AI’s official inference code.

git clone https://github.com/mistralai/mistral-inference

Links checked 3 days ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 50/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q2_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welloffloads to RAM
How well it runs on the NVIDIA Quadro RTX 8000: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.17.3 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.10.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.7.8 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score50.1 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the NVIDIA Quadro RTX 8000

Quant Memory needed Available Speed Runs Quality Download
Q2_K 61.1 GB 48.0 GB 10.8 tok/s Runs welloffloads to RAM 38Basic quality (D) · 38 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 50/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 3 (opens in a new tab)
Q3_K_M 73.8 GB 48.0 GB — Won't run 46Fair quality (C) · 46 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 6/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 2 (opens in a new tab)
Q4_K_M 90.7 GB 48.0 GB — Won't run 52Fair quality (C) · 52 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 2 (opens in a new tab)
Q5_K_M 105 GB 48.0 GB — Won't run 53Fair quality (C) · 53 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 4 (opens in a new tab)
Q6_K 120 GB 48.0 GB — Won't run 54Fair quality (C) · 54 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking.
Q8_0 154 GB 48.0 GB — Won't run 55Good quality (B) · 55 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 4 (opens in a new tab)
F16 286 GB 48.0 GB — Won't run 55Good quality (B) · 55 of 100: how capable the model is at F16, whatever it runs on. Match score 7/100 (quality, fit, speed and memory use) sets the ranking. GGUF · part 1 of 6 (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Quick answers

How much memory does Mixtral 8x22B Instruct need on the NVIDIA Quadro RTX 8000 48GB?

At Q2_K it needs about 61.1 GB. The NVIDIA Quadro RTX 8000 48GB has 48.0 GB usable.

How fast is Mixtral 8x22B Instruct on the NVIDIA Quadro RTX 8000 48GB?

About 10.8 tok/s at Q2_K, an estimate from the hardware’s memory bandwidth and the size of the model.

Which quantization of Mixtral 8x22B Instruct should I use on the NVIDIA Quadro RTX 8000 48GB?

Q2_K. Of the versions that fit, it is the one that runs best; when two run equally well, the check prefers the higher-rated one.

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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